The Nile still supports much of the population of Africans living along its banks, as well as Egyptians, the latter living between otherwise inhospitable regions of the Sahara Desert. The river flooded every summer, depositing fertile soil on the fields. The flow of the river is disturbed at several points by cataracts, which are sections of faster-flowing water with many small islands, shallow water, and rocks, forming an obstacle to navigation by boats. The sudd in the Sudan also forms a formidable obstacle for navigation and flow of water, to the extent that Egypt had once attempted to dig a canal (the Jongeli Canal) to improve the flow of this stagnant mass of water (also known as Lake No).

The Nile was, and still is, used to transport goods to different places along its long path; especially since winter winds in this area blow up river, the ships could travel up with no work by using the sail, and down using the flow of the river. While most Egyptians still live in the Nile valley, the construction of the Aswan High Dam (finished in 1970) to provide hydroelectricity ended the summer floods and their renewal of the fertile soil.

Cities on the Nile include Khartoum, Aswan, Luxor (Thebes), and the Giza-Cairo conurbation. The first cataract, the closest to the mouth of the river, is at Aswan to the north of the Aswan Dams. The Nile north of Aswan is a regular tourist route, with cruise ships and traditional wooden sailing boats known as feluccas. In addition, many “floating hotel” cruise boats ply the route between Luxor and Aswan, stopping in at Edfu and Kom Ombo along the way. It used to be possible to sail on these boats all the way from Cairo to Aswan, but security concerns have shut down the northernmost portion for many years.